Pharmaceutical formulations of ciprofloxacin

Details Pharmaceutical formulations of ciprofloxacin Pharmaceutical formulations of ciprofloxacin

1988-09-19

1994-02-15

Michl, Paul R.

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Solid synthetic organic polymer

514781, 424480, 424482, A61K 936

Patent

active

052867544

ABSTRACT:
A pharmaceutical formulation comprising by weight 30 to 95% of 1cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carb oxylic acid; 4.5 to 25% of a dry binder based on cellulose; 0 to 30% of a disintegration auxiliary based on starch; 0.5 to 10% of a disintegration auxiliary based on a cellulose derivative and/or a cross-linked polyvinyl-pyrrolidone; 0 to 2% of a flow-improving agent, and 0 to 3% of a lubricant. Tablets and capsules made from granules of the formulation, about 0.8 to 2 mm in size, exhibit high bioavailability and excellent storage stability.

REFERENCES:
patent: 4017622 (1977-04-01), Minami et al.
patent: 4620007 (1986-10-01), Grohe et al.
D. Beermann, et al. "Pharmakokinetik von Ciprofloxacin"--pp. 42-49.
Eur. J. Clin. Microbiol, Apr. 1986. pp. 187-192 "Pharmacokinetics of Ciproflaxacin after Intravenous and Increasing Oral Doses"--Bergan, et al.

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