Pharmaceutical formulations of acid labile substances for oral u

Details Pharmaceutical formulations of acid labile substances for oral u Pharmaceutical formulations of acid labile substances for oral u

1987-04-20

1989-08-01

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424468, 424475, 424479, 424480, 424482, 424456, A61K 946

Patent

active

048532304

ABSTRACT:
Pharmaceutical preparation containing an acid labile compound together with an alkaline reacting compound or an alkaline salt of an acid labile compound optionally together with an alkaline compound as the core material, one or more subcoating layers comprising inert reacting compounds which are soluble or rapidly disintegrating in water, or polymeric, water soluble filmforming compounds, optionally containing pH-buffering alkaline compounds and an enteric coating as well as a process for the preparation thereof and the use in the treatment of gastrointestinal diseases.

REFERENCES:
patent: 2540979 (1951-02-01), Clymer et al.
patent: 3131123 (1964-04-01), Masquelier
patent: 4685918 (1987-08-01), Amidon et al.
patent: 4786505 (1988-11-01), Lovgren et al.
Pilbrant, A and Cederberg, C, "Development of an Oral Formulation of Omeprazole," Scand. J. Gastroenterology, 1985, pp. 113-120.
Blanchi, A. et al., "Control of Acute Zollinger-Ellison Syndrome with Intravenous Omeprazole", The Lancet, Nov. 27, 1982, pp. 1223-1224.

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