Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1988-11-10
1991-03-12
Cashion, Jr., Merrell C.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424417, 514 37, 264 41, 264 43, 264 46, A61K 3722
Patent
active
049991990
ABSTRACT:
The present invention involves a pharmaceutical formulation comprising a liposome having a therapeutically effective concentration of an aromatic polyene macrolide antibiotic. The aromatic polyene macrolide antibiotic usable in the practice of the present invention is selected from the group consisting of candicidin, hamycin, aurefungin, ascosin, ayfattin, azacolutin, DJ400-B, trichomycin, levorin, heptamycin, candimycin or perimycin. The most preferred aromatic polyene macrolide antibiotic is candicidin. An important aspect of the present invention is a method for treating disseminated fungal infection in an animal comprising administering to an animal such as a human a pharmaceutical formulation comprising a liposome having a therapeutically effective amount of aromatic polyene macrolide antibiotic as described above. The preferred method of such administering is parenteral and the therapeutically effective amount is between about 1 mg/kg body weight and about 20 mg/kg body weight, more preferably between about 2.5 mg/kg body weight and about 6 mg/kg body weight. The parenteral administration is intravenous, intraarterial, subcutaneous, intramuscular, intralymphatic, intraperitoneal or intrapleural. The microorganisms which may be treated by the methods of the present invention comprise C. albicans, C. tropicalis, C. neoformans, aspergillus, cryptococcus, phycomycetes, fusarium, or trichosporin.
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Anaissie Elias J.
Bodey Gerald P.
Krause Hans
Samonis Georgios
Board of Regents , The University of Texas System
Cashion Jr. Merrell C.
Prater P. L.
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