Pharmaceutical formulations comprising microcapsules

Details Pharmaceutical formulations comprising microcapsules Pharmaceutical formulations comprising microcapsules

1993-06-29

1995-01-24

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 45, 424489, 424490, 424491, 424497, 514826, 514951, 514927, A61K 912, A61K 914, A61K 940

Patent

active

053841336

ABSTRACT:
Pharmaceutical formulations comprise (i) microcapsules which consist essentially of a biocompatible polymeric wall material encapsulating a drug, and (ii) a lipid soluble surfactant which is mixed with the microcapsules or is incorporated within or coats the wall material of the microcapsules. Such formulations may be presented as an aerosol or dry powder for inhalation. Microcapsules with surfactant incorporated in the wall material may be suspended in a pharmaceutically acceptable water-immiscible oil and the resulting suspension emulsified in an aqueous medium to obtain a formulation for oral administration.

REFERENCES:
patent: 4411933 (1983-10-01), Samejima
patent: 4479911 (1984-10-01), Fong
patent: 4569844 (1986-02-01), Jones
patent: 4742066 (1988-05-01), Deckner et al.
patent: 4781871 (1988-11-01), West, III et al.
patent: 4837028 (1989-06-01), Allen
patent: 4857406 (1989-08-01), Schwab
patent: 4861627 (1989-08-01), Mathiowitz
patent: 4895719 (1990-01-01), Radhakrishman et al.
patent: 4952402 (1990-08-01), Sparks
Remington's Pharm. Sci. p. 1306, 1985.
Illum and Davis: "Polymers in Controlled Drug Delivery" 1987 pp. 6 to 11.
Duncan and Seymour: "Controlled Release Technologies" pp. 21 and 23.

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