Pharmaceutical formulations

Details Pharmaceutical formulations Pharmaceutical formulations

1995-04-28

1998-04-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424456, 424489, 424463, A61K 948

Patent

active

057388717

ABSTRACT:
Hard gelatin capsules contain: (a) a fat-soluble nutrient, such as a fat-soluble vitamin (A, D, E or K) or an unsaturated fatty acid glyceride; (b) a nonionic surfactant, such as a polyoxyethylated (optionally hydrogenated) castor oil, and/or a polyethylene glycol; (c) a gelatin softening agent such as glycerol, propylene glycol or, preferably, glyceryl mono-oleate; and optionally (d) water. The problems of embrittlement conventionally encountered with hard gelatin capsules containing fat-soluble nutrients are reduced or avoided.

REFERENCES:
patent: 4572915 (1986-02-01), Crooks
patent: 4795642 (1989-01-01), Cohen
patent: 4816259 (1989-03-01), Matthews et al.
patent: 4944949 (1990-07-01), Story
patent: 5188688 (1993-02-01), Boardman et al.
patent: 5455045 (1995-10-01), Samuels et al.
English language abstract of JP 56-065820.
English language abstract of JP 1,233,218.

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