Pharmaceutical formulations

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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424 80, 424489, 424501, A61K 914

Patent

active

049976516

ABSTRACT:
The present invention relates to a new two-component pharmaceutical formulation of melphalan in which the two components comprise

REFERENCES:
patent: 3032584 (1962-05-01), Bergel et al.
patent: 3032585 (1962-05-01), Bergel et al.
patent: 4029778 (1977-06-01), Fex et al.
patent: 4738843 (1988-04-01), Oguchi et al.
Martindale, The Extra Pharmacopoeia, Twenty-eight Edition, 1982, p. 213.
British Pharmacopoeia 1988, vol. I, p. 356.
The United States Pharmacopoeia, 1985, pp. 630-631.
ABPI Data Sheet Compendium, 1986-1987, pp. 309-310.
Rote Liste, 1987 Editio Cantor, Aulendorf/Wurtt. DE.
J. of Pharm. Sci., vol. 74, No. 3, Mar. 1985, pp. 348-350, American Pharmaceutical Association, Washington, DC, US, A.G. Bosanquet: "Stability of Melphalan Solutions During Preparation and Storage".
Chem. Abst., vol. 79, No. 14, Oct. 8, 1973, p. 324, Abst. 83438d, V. P. Safonov, et al., "Hydrolysis of Sarcolysin in Aqueous Solutions of Some High-Molecular-Weight Compounds and in Hydrochloric Acid Solutions".

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