Pharmaceutical formulations

Details Pharmaceutical formulations Pharmaceutical formulations

1987-09-17

1990-07-03

Robinson, Ellis P.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424469, 424489, A61K 954

Patent

active

049389670

ABSTRACT:
The residence time in the human stomach of pharmaceutical, gastric controlled release, solid units can be increased significantly if the units have a density that is much higher than normal. A preferred oral dosage form according to the invention comprises a capsule or other dosage form having a dimension above 2 mm and that contains one or more of the said units. The density of each unit is preferably at least 2.5 and usually at least 2.7 g/ml and can conveniently be achieved by including at least 50% by weight of a weighting agent such as barium sulphate.

REFERENCES:
patent: 4193985 (1980-03-01), Bechgaard et al.
patent: 4339463 (1982-07-01), Takagishi et al.
"Symposium on the Characterisation of Porous Solids", Jul. 1978, University of Neuchatel, Robens et al.
J. Pharm. Pharmac. 1978, 30:690-692, Bechgaard et al.
Gastroenterology (1985), 89, 805-813.
J. Pharm. Pharmac. (1985), 37, 718-721, Bechgaard et al.
"Radionuclide Imaging in Drug Research" Croom Helm, London (1982), pp. 294-296, Bogentoft et al.
"Topics in Pharmaceutical Sciences" Elsevier Viomedical Amsterdam (1983), pp. 205-215, Davis.
"Scientigraphic Studies of the Behaviour of Capsules in the . . . ", 1986 European Capsul Technology Symposium, Vienna, Oct. 1986, Wilson and Washington.
Pharm. Res. (1986), 3:208-213, Davis et al.
The Pharmaceutical Codex, 11th Ed. (1979), The Pharmaceutical Press, p. 907.
Pharm. Res. (1987), 4, 78, Kaus.
J. Pharm. Pharmac. (1984), 36, 1-6.

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