Pharmaceutical formulation which does not induce tolerance

Details Pharmaceutical formulation which does not induce tolerance Pharmaceutical formulation which does not induce tolerance

1992-05-13

1994-03-22

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424456, 424458, 424459, 424460, 424461, 424462, 424463, A61K 952, A61K 922

Patent

active

052962326

ABSTRACT:
A controlled-release organic nitrate formulation for once-per-day oral administration is provided by spheres having a core which includes an organic nitrate, and a membrane surrounding the core composed of a pharmaceutically acceptable, film forming polymer. The film forming polymer is effective to permit release of the organic nitrate from the spheres, over a daily dosing period, at a rate that achieves a therapeutically effective level of the organic nitrate, while effecting a drug holiday towards a latter portion of the daily dosing period so as not to induce tolerance.

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A Copy of the Dow Chemical Company article, "Formulating for Controlled Release with METHOCEL.TM. Cellulose Ethers."
The United States Pharmacopeia, Twenty-First Revision, pp. 1243-1244.

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