Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1995-05-05
1997-08-26
Kishore, Goilamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
A61K 9127
Patent
active
056608560
ABSTRACT:
A process for preparing a liposomal cyclosporin therapeutic formulation, which comprises dissolving a combination of a neutral and negatively charged phospholipid and a cyclosporin in an organic solvent; drying the solution to form a solid phase, and hydrating the solid phase in an aqueous solution having a pH ranging from 7.5 to 9.5.
REFERENCES:
patent: 4663167 (1987-05-01), Berestein
patent: 4797285 (1989-01-01), Barenholz et al.
patent: 4952405 (1990-08-01), Young
patent: 4963362 (1990-10-01), Rahman
patent: 5000887 (1991-03-01), Tenzel et al.
patent: 5023087 (1991-06-01), Yau-Young
Deamer: Liposome Prep. Chap. 1. 1983 p. 27.
L. Stuhne-Sekalec et al. "Liposomes as Carriers of Cyclosporin A", J. Microencapsulation 8, No. 4, 441-446, Oct. 17, 1991, U.S.
L. Stuhne-Sekalec et al. "Liposomes as Cyclosporin A Carriers: the Influence of ordering Hydrocarbon Chains of Phosphatidylglycerol Liposomes on the Association with and Topography Cyclosporin A", J. Microencapsulation 8, No. 3, 283-285, Aug. 23, 1991, UK.
Szoka, Ann. Rev. Biophys. Bioeng. 1980, 9, p. 447.
Stuhne-Sekalec, Co-encapsulation of cyclosporin and insulin by liposomes, J. Biochem. Biophys. Methods 13 (1986) 23-27.
Stuhne-Sekalec, Encapsulation of cyclosporin by phosphatidylinositol-cholesterol liposomes, Tranplantation 4, 659-660 (1986).
Stuhne-Sekalec, Liposomes as cyclosporin a carriers: positively charged lecithin-cholesterol . . . phosphatidylinositol, J. Microencapsulation 6 (1969) 177-182.
Hsieh et al., Preliminary Report: The use of liposome-encapsulated cyclosporine in a rat model, Transplantation Proceedings, vol. XVII, Feb. 1985.
Venkataram, Pharmacokineitcs of two alternative dosage forms for cyclosporin: liposomes and intralipid, J. Pharm. Sci. 79, Mar. 1990.
Gruber et al., Liposomal formulation eliminates acute toxicity and pump incompatibility of parenteral cyclosporin, Pharm. Res. 6 (1989).
Stuhne-Seklac et al., Liposomes as cyclosporin a carriers: ESR study of cyclosporin a interaction with 1,2-dimyristoyl-sn-3-phosphatidylglycerol liposomes. J. Microencapsulation 8, No. 4, 455-457, Oct. 17, 1991, UK.
Adler-Moore Jill P.
Ernst William A.
Kishore Goilamudi S.
NeXstar Pharmaceuticals, Inc.
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