Pharmaceutical formulation and process

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 9127

Patent

active

056608560

ABSTRACT:
A process for preparing a liposomal cyclosporin therapeutic formulation, which comprises dissolving a combination of a neutral and negatively charged phospholipid and a cyclosporin in an organic solvent; drying the solution to form a solid phase, and hydrating the solid phase in an aqueous solution having a pH ranging from 7.5 to 9.5.

REFERENCES:
patent: 4663167 (1987-05-01), Berestein
patent: 4797285 (1989-01-01), Barenholz et al.
patent: 4952405 (1990-08-01), Young
patent: 4963362 (1990-10-01), Rahman
patent: 5000887 (1991-03-01), Tenzel et al.
patent: 5023087 (1991-06-01), Yau-Young
Deamer: Liposome Prep. Chap. 1. 1983 p. 27.
L. Stuhne-Sekalec et al. "Liposomes as Carriers of Cyclosporin A", J. Microencapsulation 8, No. 4, 441-446, Oct. 17, 1991, U.S.
L. Stuhne-Sekalec et al. "Liposomes as Cyclosporin A Carriers: the Influence of ordering Hydrocarbon Chains of Phosphatidylglycerol Liposomes on the Association with and Topography Cyclosporin A", J. Microencapsulation 8, No. 3, 283-285, Aug. 23, 1991, UK.
Szoka, Ann. Rev. Biophys. Bioeng. 1980, 9, p. 447.
Stuhne-Sekalec, Co-encapsulation of cyclosporin and insulin by liposomes, J. Biochem. Biophys. Methods 13 (1986) 23-27.
Stuhne-Sekalec, Encapsulation of cyclosporin by phosphatidylinositol-cholesterol liposomes, Tranplantation 4, 659-660 (1986).
Stuhne-Sekalec, Liposomes as cyclosporin a carriers: positively charged lecithin-cholesterol . . . phosphatidylinositol, J. Microencapsulation 6 (1969) 177-182.
Hsieh et al., Preliminary Report: The use of liposome-encapsulated cyclosporine in a rat model, Transplantation Proceedings, vol. XVII, Feb. 1985.
Venkataram, Pharmacokineitcs of two alternative dosage forms for cyclosporin: liposomes and intralipid, J. Pharm. Sci. 79, Mar. 1990.
Gruber et al., Liposomal formulation eliminates acute toxicity and pump incompatibility of parenteral cyclosporin, Pharm. Res. 6 (1989).
Stuhne-Seklac et al., Liposomes as cyclosporin a carriers: ESR study of cyclosporin a interaction with 1,2-dimyristoyl-sn-3-phosphatidylglycerol liposomes. J. Microencapsulation 8, No. 4, 455-457, Oct. 17, 1991, UK.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pharmaceutical formulation and process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical formulation and process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical formulation and process will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1986489

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.