Pharmaceutical formulation and process

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 9127, A61K 9133

Patent

active

056885253

ABSTRACT:
A process for preparing a liposomal cyclosporin therapeutic formulation, which comprises dissolving a combination of a neutral and negatively charged phospholipid and a cyclosporin in an organic solvent; drying the solution to form a solid phase, and hydrating the solid phase in an aqueous solution having a pH ranging from 7.5 to 9.5.

REFERENCES:
patent: 4663167 (1987-05-01), Berestein
patent: 4797285 (1989-01-01), Barenholz et al.
patent: 4952405 (1990-08-01), Young
patent: 4963362 (1990-10-01), Rahman et al.
patent: 5000887 (1991-03-01), Tenzel et al.
patent: 5023087 (1991-06-01), Yau-Young
Szoka Ann. Rev. Biophys. Bioeng. 1980, 9, p. 467.
Deamer; Liposome Prep. Chap. I, 1983 p. 27.
Stuhne-Sekalec, Co-encapsulation of Cyclosporin and Insulin by Liposomes, J. Biochem. Biophys. Methods 13 (1986) 23-27.
Stuhne-Sekalec, Encapsulation of Cyclosporine by Phosphatidylinositol-Cholesterol Liposomes, Transplantation 41, 659-660 (1986).
Stuhne-Sekalec, Liposomes as Cyclosporin A carriers: positively charged lecithin-cholesterol . . . phosphatidylinositol, J. Microencapsulation 6 (1969) 177-182.
Hsieh et al, Preliminary Report: The Use of Liposome-Encapsulated Cyclosporine in a Rat Model, Transplantation Proceedings, vol. XVII, Feb. 1985.
Venkataram, Pharmacokinetics of Two Alternative Dosage Forms for Cyclosporine: Liposomes and Intralipid, J. Pharm. Sci. 79, Mar. 1990.
Gruber et al., Liposomal Formulation Eliminates Acute Toxicity and Pump Incompatibility of Parenteral Cyclosporine, Pharm. Res. 6 (1989).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pharmaceutical formulation and process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical formulation and process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical formulation and process will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1563887

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.