Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-02
1998-12-15
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 530362, 530363, 530397, 530399, A61K 3702, A61K 4710, A61K 4726
Patent
active
058497048
ABSTRACT:
A pharmaceutical preparation comprising a growth hormone and histidine or a derivative of histidine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved preparation at ambient temperature. Crystallization of growth hormone in the presence of histidine or a derivative thereof gives rise to a higher yield of crystals having a higher purity than known methods.
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Hoelgaard Annie Rassing
S.o slashed.rensen Hans Holmegaard
Skriver Lars
Argis Cheryl H.
Novo Nordisk A S
Schain Howard E.
Touzeau Lynn
Zelson Steve T.
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