Pharmaceutical formulation

Details Pharmaceutical formulation Pharmaceutical formulation

1994-10-13

1996-08-20

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 514 21, 514 2, A61K 914, A61K 908, A61K 3827

Patent

active

055476961

ABSTRACT:
A pharmaceutical formulation comprising a growth hormone and valine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.

REFERENCES:
patent: 4537769 (1985-08-01), Cerini
patent: 4915945 (1990-04-01), Pelzer
patent: 4917685 (1990-04-01), Viswanathan
patent: 5041378 (1991-08-01), Drummond
Wang et al., J. Parenteral Sci. & Tech., Vo. 42, pp. s3-s26 (1988).
Manning et al., Pharma. Research, vol. 6. No. 11, pp. 903-918 (1989).
Becker et al., Biotech. and Applied Biochem., vol. 9, 478-487 (1987).
Johnson et al., J. Biol. Chem., vol. 264, No. 24, pp. 14262-14271 (1989).
Becker et al., Biotech. and Applied Biochem., vol. 10, 326-337 (1988).
Houghten et al., Ach. Biochem. & Biophy., vol. 178, pp. 350-355 (1977).
Teh et al., J. Biological Chem., vol. 262, No. 14, pp. 6472-6477 (1987).
Riggin et al., Analytical Biochem., vol. 167, pp. 199-209 (1987).
Gellerfors, Acta P.ae butted.diatr Scand [Suppl], vol. 370, pp. 93-100 (1990).
Kaufman, Pharmaceutical Research, vol. 7, No. 3, pp. 289-293 (1990).
Dialog accession No. 004842401, WPI accession No. 86-345742/52.
Dialog accession No. 007545021, WPI accession No. 88-178953/26.

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