Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Wearing apparel – fabric – or cloth
Patent
1997-09-18
2000-09-12
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Wearing apparel, fabric, or cloth
424 7802, 424 7803, 424402, 424449, 424490, 424494, A61K 3174, A01N 2534
Patent
active
061174378
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
In the treatment of wounds, it is necessary for active substances which are intended or need to come into direct contact with the surface of the wound or the bottom of the wound to be administered by means of pharmaceutical forms which, by reason of their consistency, can be applied without gaps even to very uneven surfaces. This normally takes place with the aid of solutions, powders, dusting powders, sprays, semisolid preparations, such as ointments, creams and gels. The disadvantages of these pharmaceutical forms become clear, in particular, when it is necessary to give doses of highly active substances in a small amount, accurately and reproducibly, or when controlled release from the pharmaceutical form is desirable for the therapy to maintain a uniform concentration of active substance in the wound throughout a particular period.
Wound dressings which, by reason of their composition and their structure, are loaded with active substances and release the latter in a delayed or controlled manner are described, for example, in U.S. Pat. No. 5,098,417, in EP 49 177 or in DE-B 11 90 608. These wound dressings have the disadvantage that, especially in the case of deep wounds, they do not come into contact with the bottom of the wound. The ability of such wound dressings to function is, moreover, greatly dependent on the interaction with wound fluid, since, the release can take place only by diffusion of the active substance at the interface between wound dressing and wound fluid or by erosion of the active substance from the wound dressing after uptake of fluid and swelling of the carrier material. Since the fluid conditions in wounds vary greatly between individuals and depending on the type of wound and phase of wound healing, it is not possible to achieve comparable and reproducible kinetics of release with such wound dressings in vivo.
BRIEF DESCRIPTION OF THE INVENTION
The present of the present invention is based on the object of forming a pharmaceutical form which, on the one hand, permits an accurate and reproducible dose of active substance to be given and the release of active substance to be controlled reliably and which, on the other hand, corresponding to the traditional pharmaceutical forms mentioned at the outset, can be adapted to uneven wound surfaces even with deep wounds and can be brought into contact therewith. It has surprisingly been found that this is achieved by a deformable, sheet-like pharmaceutical form which delivers active substance, is coherent and is designed to be in its sheet-like extent equal to or smaller than the wound area to be managed and which contains the active substance in defined amounts in homogeneously dispersed form. Further embodiments of the pharmaceutical form are described below.
Conventional deformable pharmaceutical forms which deliver active substance and which, after application into the wound, form sheet-like structures such as, for example, gels, ointments, creams or else liquid multicomponent systems which, after mixing in the wound, react together with solidification, belong, according to the specialist terminology, to the so-called multiple dose pharmaceutical forms. This means that the amount of the pharmaceutical form present in one container is intended for a plurality of uses with appropriate dosing procedures. The dosage itself is performed by the individual user. The user is able to make statements about the amount of active substance in the dose only if he weighs the particular dose before use. On repeated use, reproducible application of a constant amount of active substance would be possible only with the aid of a weighing procedure beforehand. This individually variable dosage is possible only because of the low coherence and easy divisibility of these pharmaceutical forms. On the other hand, the low coherence has the advantage that the pharmaceutical form can be, as mentioned, deformed as required and can be adapted to uneven surfaces.
By contrast, the pharmaceutical form according to the invention is a s
REFERENCES:
patent: 4834978 (1989-05-01), Nuwayser
patent: 5098417 (1992-03-01), Yamazaki et al.
Dees Jos,e G.
LTS Lohmann Therapie-Systeme GmbH
Shelborne Kathryne E.
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