Pharmaceutical for treating tumors and method for making it

Details Pharmaceutical for treating tumors and method for making it Pharmaceutical for treating tumors and method for making it

1988-04-06

1989-11-21

Rosen, Sam

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

514 2, 424105, 530323, 530324, 530412, 530853, 530850, C07K 302, C07K 312

Patent

active

048824216

ABSTRACT:
Rana pipiens eggs are subjected to fertilization and the embryos are grown to a predetermined stage of development. The embryos and unfertilized eggs are then subjected to mechanical processing in the presence of a weakly acidic buffer to produce an extract. The extract is subjected to ion-exchange chromatography and size-exclusion chromatography.
The resulting pharmaceutical has activity against certain cancer cells. A partial amino acid sequence of the pharmaceutical is disclosed.

REFERENCES:
patent: 4112074 (1978-09-01), Truffier et al.
patent: 4340591 (1982-07-01), Lucotte et al.

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