Pharmaceutical excipient having improved compressibility

Details Pharmaceutical excipient having improved compressibility Pharmaceutical excipient having improved compressibility

1997-12-17

2000-08-15

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Dentifrices

424464, 424489, 424494, 424495, 424496, 424497, 10615451, A61K 716, A61K 926, A61K 932, A61K 916

Patent

active

061032190

ABSTRACT:
A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.

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Machines Collette High Shear Mixer Granulator Promotional Literature (date unknown).

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