Pharmaceutical excipient having improved compressability

Details Pharmaceutical excipient having improved compressability Pharmaceutical excipient having improved compressability

1995-01-09

1996-12-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424480, 424470, 424469, 424494, A61K 914

Patent

active

055851150

ABSTRACT:
A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.

REFERENCES:
patent: 3141875 (1964-07-01), Battista
patent: 4159345 (1979-06-01), Takeo
patent: 4664915 (1987-05-01), Simonian
patent: 4744987 (1988-05-01), Mehra
patent: 4946685 (1990-08-01), Edgren et al.
patent: 5126145 (1992-06-01), Evenstad et al.
patent: 5322698 (1994-06-01), Kovacs et al.

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