Pharmaceutical dosage unit forms with delayed release

Details Pharmaceutical dosage unit forms with delayed release Pharmaceutical dosage unit forms with delayed release

1989-08-01

1991-04-30

Page, Thurman

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424462, 424468, 424473, 424 81, 427336, A61K 920

Patent

active

050116940

ABSTRACT:
Improved delayed release pharmaceutical dosage unit forms such as tablets are obtained by exposing a matrix of a compressed mixture of active pharmaceutical ingredient and of a polyacrylic ester polymer or a vinyl ester polymer insoluble in body fluids at the point of release to vapors of a lower alcohol.

REFERENCES:
patent: 2987445 (1961-06-01), Levesque
patent: 3087860 (1963-04-01), Endicott
patent: 3148124 (1964-09-01), Gaunt
patent: 4013820 (1977-03-01), Farhadieh
patent: 4851233 (1989-07-01), Khan
patent: 4853249 (1989-08-01), Takashima
Journal of Pharmaceutical Sciences, 60 (2), 212-215 (1971), Farhadieh et al., "Drug Release from Methyl-Acrylate-Methyl Methacrylate Copolymer Matrix II: Control of Release Rate by Exposure to Acetone Vapor".

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