Pharmaceutical depot compositions containing hirudin

Details Pharmaceutical depot compositions containing hirudin Pharmaceutical depot compositions containing hirudin

1994-02-17

1995-12-05

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 21, 514769, 514770, 514822, 514970, A61K 3817, A61K 4702

Patent

active

054729386

ABSTRACT:
The present invention relates to aqueous depot formulations of hirudin, particularly desulphatohirudin, which are very stable. These formulations contain water, hirudin, and calcium, magnesium, or zinc ions in the form of water insoluble salts, the salts being in a concentration of from 100 mM to 600 mM.

REFERENCES:
patent: 2487600 (1949-11-01), Schneiderwirth
patent: 3027229 (1962-03-01), Towey et al.
patent: 5118790 (1992-06-01), Winant et al.
patent: 5192747 (1993-03-01), Krstenansky
patent: 5204323 (1993-04-01), Findlay et al.

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