Pharmaceutical dental formulation for topical application of met

Details Pharmaceutical dental formulation for topical application of met Pharmaceutical dental formulation for topical application of met

1997-10-31

2000-01-25

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Dentifrices

Hydroxy carboxylic acid or derivative thereof

424 49, A61K 724, A61K 716

Patent

active

060175168

ABSTRACT:
A pharmaceutical dental formulation of therapeutically effective amounts of metronidazole benzoate and chlorhexidine gluconate is described. The formulation also includes a gelled hydrophilic and water-dipersible polymer having free carboxylic groups, an aqueous base, a penetration enhancer and a chelating agent. The formulation is for topical application in the form of an aqueous gel in the treatment of periodontal diseases including gingivitis, stomatitis, Apthous ulcers and post-extraction infection.

REFERENCES:
patent: 5143934 (1992-09-01), Lading et al.
patent: 5262164 (1993-11-01), Damani et al.
V. Pedrazzoli et al J. Clin. Periodont. 1992:19:715-722 "Comparative Clinical . . . ".
J. Ainamo et al J. Clin. Periodont. "Clinical Responses . . . " 1992:19:723-729.
D.F. Hoyos et al Brit. dent. J. 1977, 142, 366.

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