Pharmaceutical delivery systems

Details Pharmaceutical delivery systems Pharmaceutical delivery systems

1987-12-17

1990-07-31

Chaudhuri, Olik

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424455, 424456, 514825, 514937, 514941, A61K 966

Patent

active

049449494

ABSTRACT:
Non-steroidal anti-inflammatory drugs (NSAIDs) including diclofenac, flufenamic acid, flurbiprofen, ibuprofen, indomethacin, ketoprofen, naproxen, phenylbutazone, piroxicam and sulindac are administered in micelles to alleviate their adverse effects on the gastrointestinal tract. The drugs are formulated with surfactants such as polyethoxylated nonionics to give micelle-forming compositions.

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Schott et al., The Role of Surfactants in the Release of Very Slightly Soluble Drugs from Tablets, 1982, 71 J. Pharm. Sci., 1038.
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Chemical Abstracts DT 2902-672.
Chemical Abstracts 104:193025j.
Chemical Abstracts 104:135951x.
Chemical Abstracts 104:10512y.
Chemical Abstracts 103:183432c.
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Paradies, H. "Structure of Phenylbutazone and Mofebutazone in the Crystalline State and in Solution", J. Pharm Sci., 76(12), 920-929.
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Chemical Abstracts 85:166564s; 104:155882d; 104:155883e; 108:192665p; 106:6723s; 94:52771n.

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