Drug – bio-affecting and body treating compositions – Extract or material containing or obtained from a...
Reexamination Certificate
1999-05-25
2001-08-07
Tate, Christopher R. (Department: 1651)
Drug, bio-affecting and body treating compositions
Extract or material containing or obtained from a...
C424S725000, C424S736000, C424S747000, C424S115000, C424S401000, C514S886000, C514S887000
Reexamination Certificate
active
06270811
ABSTRACT:
BACKGROUND OF THE INVENTION
It is known from the EP-0 043 128 B1 corresponding to U.S. Pat. No. 4,464,362 document of a cosmetic composition based on a “complex” of active substances which promote the process of repair of DNA of the cells of the skin based on an inactivated culture of bacteria of the genus Bifidobacterium or of bacteria related to this genus (see claim
1
and the description).
This document describes a DNA repairing effect which is demonstrated by comparative tests wherein tissue DNA is damaged in vitro or in vivo by a UV lamp and wherein it is demonstrated that the complex of active substances formed by inactivated cultures of Bifidobacterium produces a significant repairing effect.
This document also contains various examples of embodiments in which this complex is used in combination with various mixtures of esters of high molecular weight some of which can be alcoholic esters of citric acid.
SUMMARY OF THE INVENTION
Within the context of the present invention, tests have been made on wrinkles as well as on several years old-scars which can be up to about twenty years old, with a composition in accordance with the examples in this document and no significant anti-wrinkle effect nor any apparent effects on the appearance of such old scars was noted.
The present inventor has, in new tests, prepared a mixture of an inactivated culture of Bifidobacterium or of bacteria related to this genus with an essential oil as well as an acid, preferably an organic acid, in particular a fatty acid, such as citric acid, and has demonstrated the unexpected obtaining of a significant anti-wrinkle effect as well as a significant effect of erasing old scars. These significant effects are quantifiable as from the first application. It has also been possible to observe a significant effect in relation to the repair of scars left by buns, promoting skin healing, removing pigment marks and also promoting the growth or the re-growth of the integuments, i.e. the nails, the hair or the hairs.
The present inventor, during even more tests, has unexpectedly discovered that the use of pollen from flowers, which contains a significant number of fermentation micro-organisms or ferments, or of its aqueous or organic extracts, in particular lipidic extracts, which is collected or not by bees, and which is non-fermented or fermented, constitutes an active principle of a cosmetic or pharmaceutical composition, in particular having an anti-wrinkle, smoothening, skin texture improving, lightening, scar diminishing, skin surface moisturising, skin softening, perfuming, skin regenerating effect. It has also been possible to unexpectedly observe that this activity was radically reinforced if the pollen was combined with a plant essential oil, in particular with an essential oil of mint, preferably peppermint, of rosemary, of lemon and more if this combination was also prepared with an acid, preferably an organic acid, in particular a fatty acid. Advantageously, the acid mentioned above is selected from citric acid used as such or in the form of a derivative such as a salt or ester and especially an alcoholic ester, or a citrus fruit juice such as lemon juice, orange juice, lime juice, grapefruit juice, clementine juice, mandarin juice, or an essential oil of lemon or of orange or of other extracts which are rich in citric acid or tartaric acid, or ascorbic acid or lactic acid.
More generally, the present inventor has discovered that a microbial culture compatible in cosmetics or in pharmacy, in particular a culture of micro-organisms selected from acetic or lactic bacteria, lyophilised yeasts, suspensions of micro organisms, fermented organic materials, for example pollen, preferably fermented pollen, or an inactivated culture of bacteria of the genus Bifidobacterium or of bacteria related to this genus, constitutes an active principle of a cosmetic or pharmaceutical composition, having the activities mentioned above which are particularly powerful in a mixture with an essential oil and an acid.
DESCRIPTION OF THE INVENTION
Thus, according to a first aspect, the present invention relates to the use of a microbial culture compatible in cosmetics or in pharmacy, in particular a culture of micro-organisms selected from acetic or lactic bacteria, lyophilised yeasts, suspensions of micro-organisms, fermented organic materials, for example pollen, preferably fermented pollen, or an inactivated culture of bacteria of the genus Bifidobacterium or of bacteria related to this genus in a mixture with an essential oil and an acid, preferably an organic acid, in particular a fatty acid, as cosmetic agent, or for preparing a pharmaceutical composition especially having an activity for regenerating the skin, particularly an anti-wrinkle activity, for erasing old scars, for repairing scars left by burns, for promoting skin healing, for removing pigment marks and also for promoting growth or re-growth of integuments, comprising nails and hair or hairs.
It is to be noted that these effects are obtained without notable side effect and especially without comedogenic effect and without allergenic effect and without hyperaemia. It is to be noted that in order to guarantee an absence of hyperaemia, it is in general necessary to use an amount of acid, preferably an organic acid, in particular a fatty acid, such as citric acid, of less than or equal to about 30%.
According to a second aspect, the present invention also covers a cosmetic or pharmaceutical composition, characterised in that it comprises a microbial culture compatible in cosmetics or in pharmacy, in particular a culture of micro-organisms selected from acetic or lactic bacteria, lyophilised yeasts, suspensions of micro-organisms, fermented organic materials, for example pollen, preferably fermented pollen, or an inactivated culture of bacteria of the genus Bifidobacterium or of bacteria related to this genus, in a mixture with an essential oil and an acid, preferably an organic acid, in particular a fatty acid.
According to an advantageous embodiment of the invention, and in the context of any one of its aspects, the microbial culture mentioned above is used at a concentration of micro-organisms of at least 1 million, preferably of at least 10 million per gram of culture of micro-organisms. “Culture” is understood as meaning the crude culture media or those resulting from a physical separation such as a filtration, centrifugation, which are well known to the person skilled in the art and which are also described further on in relation to the pollen.
It is possible for this microbial culture to be constituted of about 1 to about 90% by weight of the final composition but in general it will be possible to vary, within preferred concentrations as indicated according to the variants below.
According to an embodiment variant of the invention, about 1 to about 90% by weight and preferably about 50 to about 60% by weight of an inactivated culture of bacteria of the genus Bifidobacterium or of bacteria related to this genus can be incorporated.
According to another implementation variant of the invention, when fermented organic materials are involved, for example non-fermented or fermented pollen, it is currently preferred to incorporate about 1 to about 90% by weight, preferably about 1 to about 30%, more preferably about 1 to about 10% and more preferably between about 1 and about 5% of such fermented organic materials, preferably constituted of fermented pollen.
As regards the acid, this will generally be added at a proportion of about 1 to about 50% by weight and preferably about 5 to about 40% by weight and more preferably between about 5 and about 30% by weight.
In either of the aspects of the present invention, it is currently preferred to use as acid citric acid as such or in the form of a derivative such as a salt or ester and especially an alcoholic ester, or a citrus fruit juice, such as lemon juice, orange juice, lime juice, grapefruit juice, clementine juice, mandarin juice, or an essential oil of lemon or of orange or of other extracts which are rich i
1 Fois 1 Jour Concept
Dennison, Scheiner Schultz & Wakeman
Tate Christopher R.
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