Pharmaceutical controlled-release composition with bioadhesive p

Details Pharmaceutical controlled-release composition with bioadhesive p Pharmaceutical controlled-release composition with bioadhesive p

1993-12-27

1995-12-05

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424473, 424486, 424487, 424488, A61K 916

Patent

active

054727049

ABSTRACT:
A pharmaceutical composition for the controlled release of medicinal drugs, which has the property of adhering to biologic tissues is described. The characteristic features of the composition are a plurality of small-size units capable of ensuring a gradual release of the active ingredient they contain the units being coated with a bioadhesive polymer layer. The composition makes it possible to keep the release controlling function separate from the function providing bioadhesion and can be adapted inter alia to oral, ocular, rectal, vaginal, nasal or periodontal administrations. An advantageous process for making the composition is also disclosed.

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Lehr et al., J. of Controlled Release 13: 1, 51-62, Jul., 1990.
An In-Vitro Investigation of Mucosa-Adhesive Materials for Use in Controlled Drug Delivery, Smart et al., J. Pharm. Pharmacol. 1984, 36:295-99.
In Vitro Method to Evaluate Bioadhesion of Microparticles, Sala et al., Proceed. Intem. Symp. Control. Rel. Bioact. Mater., 16(1989), Controlled Release Society, Inc., pp. 420-421.
The Gastric Emptying of Hard Gelatin Capsules, Hunter et al., International Journal of Pharmaceutics, 17 (1983) 59-64.
Bioadhesion-Possibilities and Future Trends, Kellaway, Course No. 470, May 22-24, 1989.
Experimental Methods for Determination of Bioadhesive Bond Strength of Polymers with Mucus, Peppas et al., S. T. P. Pharma 5(3) 187-191, 1989.
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