Pharmaceutical control of inflammation

Details Pharmaceutical control of inflammation Pharmaceutical control of inflammation

1997-03-21

2000-05-23

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424463, 424489, 424461, A61K 920

Patent

active

060663332

ABSTRACT:
Control of inflammation is achieved by control of the level and/or activity of the enzyme heme-oxygenase (HO). A HO inducer is anti-inflammatory (FIG. 14) and used to treat inflammation, such as chronic inflammatory diseases. A HO inhibitor promotes inflammation and is used to treat immunosuppressed conditions. Alternative, or additional, control of heme-oxygenase activity is achieved by control of nitric oxide levels, elevated levels promoting inflammation.

REFERENCES:
patent: 4699903 (1987-10-01), Rideout et al.
patent: 5010073 (1991-04-01), Kappas et al.
patent: 5102670 (1992-04-01), Abraham et al.
Cantoni, L. et al., "Interleukin-1 and tumor necrosis factor induce hepatic haem oxygenase: Feedback regulation by glucocorticoids," Biochem. J. 279:891-894 (1991).

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