Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2007-07-03
2010-11-30
Balasubramanian, Venkataraman (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C514S241000
Reexamination Certificate
active
07842805
ABSTRACT:
Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
REFERENCES:
patent: 6235752 (2001-05-01), Yuan et al.
patent: 6492360 (2002-12-01), Napoletano et al.
patent: 6498159 (2002-12-01), Watanabe et al.
patent: 6514971 (2003-02-01), Thomas et al.
patent: 6589951 (2003-07-01), Napoletano et al.
patent: 2004/0176603 (2004-09-01), Priepke et al.
patent: 0049029 (1982-04-01), None
patent: 02129183 (1990-05-01), None
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition,vol. 1, 1004-1010, 1996.
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Vippagunta et al., Advanced Drug Delivery Reviews 48: 3-26, 2001.
Wood et al., Current Opinion in Pharmacology, 1,370-377, 2001.
Andoh et al., Advances in Pharmacology, 29B, 93-103, 1994.
Denny et al., Expert Opin. Emerg. Drugs, 9(1), 105-133, 2004.
Ruchelman et al., Biorganic & Medicinal Chemistry, 12, 795-806, 2004.
Jordan et al., Biochemistry 39(29), 8593-8602, 2000.
Chen et al., Biochemistry 37(51), 17735-17744, 1998.
Gilbert et al., Journal of Heterocyclic Chemistry, 6(6), 779-782, 1969.
Clark et al., Journal of Chemical Research Synopsis, 2, 62-63, 1984; CA 101: 6506, 1984.
Bold et al., “New anilinophthalzines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis”,Journal of Medicinal Chemistry, 2000, 43(16):3200.
Bold et al., “New anilinophthalzines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis”,Journal of Medicinal Chemistry, 2000, 43(12):2310-2323.
Bystrkh et al., “Spectra and structure of 1-aminophthalazines”,Khimiya Geterotsiklicheskikh Soedinenii, 1983, 6:826-833.
Dalla Croce, “Reactivity of Me Cholor(phenylhydrazono)acetate with some diazines”,Journal of Heterocyclic Chemistry, 1975, 12(6):1133-1134.
Anderson Mark B.
Cai Sui Xiong
Halter Robert J.
Jiang Songchun
Klimova Yevgeniya
Balasubramanian Venkataraman
Echols Kelly A.
EpiCept Corporation
I.P. Group; Myrexis, Inc.
Ley, III Herbert L.
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