Pharmaceutical compositions with galactitol as carrier

Details Pharmaceutical compositions with galactitol as carrier Pharmaceutical compositions with galactitol as carrier

1986-06-26

1989-01-10

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514110, A61K 3166, A61K 3170, A61K 4700

Patent

active

047973889

ABSTRACT:
An improved pharmaceutical composition contains galactitol as carrier for the therapeutic agent. One example is a lyophilized composition of about 20 parts by weight of cyclophosphamide, taken as the anhydride, about 5 to 21 parts by weight of galactitol as excipient, and about 1.4 to 3 parts by weight of water. Preferably, the amount of galactitol is 15-21 parts by weight. The galactitol enhances the chemical and physical stability of the drug and allows faster reconstitution of the formulation in water than mannitol.

REFERENCES:
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patent: 3944625 (1976-03-01), Neal
patent: 3993781 (1976-11-01), Horvath et al.
patent: 4418058 (1983-11-01), Hirai et al.
patent: 4446134 (1984-05-01), Naito et al.
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patent: 4604377 (1986-08-01), Fernandes et al.
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Kovalcik et al., Journal of Parenteral Science and Technology, vol. 42, No. 1, pp. 29-38 (1988).

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