Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1979-11-14
1981-08-18
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
424263, 546196, 546217, 546269, A61K 31445
Patent
active
042846382
ABSTRACT:
The invention relates to pharmaceutical compositions which contain, as active ingredients, a butyrophenone derivative I which is basically substituted in the 4-position and has central depressant and antipsychotic activity, or a pharmaceutically acceptable acid addition salt thereof, and an unsubstituted or substituted C-(2-benzofuranyl)-piperidine or C-(2-benzofuranyl)-tetrahydropyridine of the general formula II ##STR1## wherein R.sub.1 is hydrogen, an alkyl group containing at most 4 carbon atoms, the allyl, 3-oxobutyl, 3-hydroxybutyl, 2-propynyl or cyclopropylmethyl group, R.sub.2 is hydrogen or a methyl group, R.sub.3 is hydrogen, halogen having an atomic number up to 35, a lower alkyl or alkoxy group, the trifluoromethyl group or a cycloalkyl group containing 5 to 8 carbon atoms, R.sub.4 is hydrogen, a lower alkyl group or halogen having an atomic number up to 35, or R.sub.3 and R.sub.4 together are a 1,3-butadienylene radical in the 4,5-position, corresponding to a fused benzene ring, or a trimethylene radical in the 5,6-position, A is the ethylene group and B is the methylene group, or A is the methylene group and B is the ethylene group, and each of X and Y is hydrogen or together are an additional bond, or a pharmaceutically acceptable acid addition salt thereof.
REFERENCES:
patent: 3097209 (1963-07-01), Janssen
patent: 3161645 (1964-12-01), Janssen
patent: 3438991 (1969-04-01), Janssen
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patent: 4210655 (1980-07-01), Schenker et al.
C. J. Carter and C. J. Pycock, in (Proceedings Mar., 1977) "British Journal of Pharmacology", vol. 60, pp. 267 P-268 P, (1977).
G. Stille, "Schweizerische Medizinische Wochenschrift", vol. 99, pp. 1645-1654 and 1690-1693, (1969).
Chemical Abstracts, Index Guide, (1977), p. 485 G and p. 825 G.
Waldmeier et al., European J. of Pharmacology, vol. 55, (1979), pp. 363-373.
Delini-Stula Aleksandra
Waldmeier Peter
Almaula Prabodh I.
Bond Robert T.
Ciba-Geigy Corporation
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