Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-08-11
2010-10-12
Krass, Frederick (Department: 1612)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S455000, C424S423000, C549S389000
Reexamination Certificate
active
07812051
ABSTRACT:
The present invention relates to polymer-modified quinone-containing and carbonyl-containing therapeutic agents, including polymer-modified β-lapachone compounds, and methods of treating cancer by administering the polymer-modified therapeutic agents to a subject. Polymer-modification of therapeutic agents, such as β-lapachone compounds, provides effective transport of polymer-modified therapeutic agents to tumor cells or tumor tissues by exploiting the EPR effect in tumor tissues.
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Ashwell Mark A.
Jiang Zhiwei
LaPierre Jean-Marc
Li Chiang J.
Liu Yanbin
ArQule, Inc.
Elrifi, Esq. Ivor R.
Krass Frederick
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
Pavao, Esq. Matthew
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