Pharmaceutical compositions of microbially produced interleukin-

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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530351, 424 85, 424 87, 424 88, 435 68, 435 70, 4351723, 435240, 435241, 435948, 514 2, 935 11, 935 12, A61K 4502, A61K 3702, A61K 3939, C07K 1300

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active

046043772

ABSTRACT:
A sterile, stable lyophilized formulation of selectively oxidized microbially produced recombinant IL-2 in which the recombinant IL-2 is admixed with a water soluble carrier such as mannitol that provides bulk, and a sufficient amount of sodium dodecyl sulfate to ensure the solubility of the recombinant IL-2 in water. The formulation is suitable for reconstitution in aqueous injections for parenteral administration and it is stable and well tolerated in human patients. FIG. 1 illustrates a preferred method of purifying recombinant IL-2 suitable for use in preparing the formulations of the present invention.

REFERENCES:
patent: 4401756 (1983-08-01), Gillis
patent: 4490289 (1984-12-01), Stern
patent: 4518584 (1985-05-01), Mark et al.
patent: 4530787 (1985-07-01), Shaked et al.
Morgan et al., Science (1976), 193:1007-1008.
Taniguchi et al., Nature (1983), 302, 305-310.
Devos et al., Nucleic Acids Research (1983), 11, 4307-4323.

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