Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1985-03-21
1986-08-05
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530351, 424 85, 424 87, 424 88, 435 68, 435 70, 4351723, 435240, 435241, 435948, 514 2, 935 11, 935 12, A61K 4502, A61K 3702, A61K 3939, C07K 1300
Patent
active
046043772
ABSTRACT:
A sterile, stable lyophilized formulation of selectively oxidized microbially produced recombinant IL-2 in which the recombinant IL-2 is admixed with a water soluble carrier such as mannitol that provides bulk, and a sufficient amount of sodium dodecyl sulfate to ensure the solubility of the recombinant IL-2 in water. The formulation is suitable for reconstitution in aqueous injections for parenteral administration and it is stable and well tolerated in human patients. FIG. 1 illustrates a preferred method of purifying recombinant IL-2 suitable for use in preparing the formulations of the present invention.
REFERENCES:
patent: 4401756 (1983-08-01), Gillis
patent: 4490289 (1984-12-01), Stern
patent: 4518584 (1985-05-01), Mark et al.
patent: 4530787 (1985-07-01), Shaked et al.
Morgan et al., Science (1976), 193:1007-1008.
Taniguchi et al., Nature (1983), 302, 305-310.
Devos et al., Nucleic Acids Research (1983), 11, 4307-4323.
Fernandes Pete M.
Taforo Terrance A.
Cetus Corporation
Halluin Albert P.
Schain Howard E.
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