Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-12-17
1995-10-17
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5483601, A61K 31415
Patent
active
054591589
ABSTRACT:
Indazoles of Formula (I) ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each separately selected from hydrogen, halogeno, halogenoalkyl, formyl, carboxy, sulpho, cyano, nitro, COR and .sup.+ NRR'R" groups, wherein R, R' and R" are each separately alkyl, aralkyl or aryl groups, and R.sub.5 is selected from hydrogen, halogeno, halogenoalky, formyl, carboxy, sulpho, cyano, nitro, hydroxy, alkoxy, alkyl, COR, NHCOR and .sup.+ NRR'R" groups, wherein R, R' and R" are each separately alkyl, aralkyl or aryl groups, which may optionally be in the form of a physiologically acceptable ester or salt, are of value for use as an analgesic or in the treatment of any condition where the inhibition of brain/spinal cord nitric oxide synthase is advantageous, for example in neurodegenerative disease.
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Babbedge Rachel C.
Moore Philip K.
Burroughs Wellcome Co.
Springer David B.
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