Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-10-25
1993-11-02
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
549210, A61K 31555
Patent
active
052583767
ABSTRACT:
Disclosed are pharmaceutical compositions that comprise gallium complexes of 3-hydroxy-4-pyrones. These compositions provide enhanced gallium bioavailability particularly when orally administered as compared to the gallium bioavailability achieved by use of pharmaceutical compositions containing gallium salts. Compositions included in this invention are useful in providing gallium to humans and other mammals for a wide variety of medical and veterinary applications, including the treatment, prevention, or diagnosis of hypercalcemia, certain cancers, certain disorders of calcium homeostasis, and certain bone diseases including osteoporosis, osteopenia, and Paget's disease.
REFERENCES:
patent: 2460188 (1949-01-01), O'Kane
patent: 3799945 (1974-03-01), D'Amico
patent: 3927195 (1975-12-01), Messora
patent: 4529593 (1985-07-01), Warrell, Jr. et al.
patent: 4575502 (1986-03-01), Hider et al.
patent: 4596710 (1986-06-01), Collery
patent: 4665064 (1987-05-01), Hider et al.
patent: 4704277 (1987-11-01), Bockman et al.
patent: 5175006 (1992-12-01), Matkovic et al.
patent: 5177068 (1993-01-01), Callingham
patent: 5196412 (1993-03-01), Bradley et al.
Allen et al. Jour. Neurochemistry, vol. 58 (1992).
Shah, Chem. Abstr., vol. 116, entry 136251d (1991) abstracting WO91-17751.
Hider et al. Chem. Abstr., vol. 116, entry 59225u (1991) abstracting GB 2242191.
Hart and Adamson, Proceedings of the National Academy of Sciences, U.S.A., 68:1623-1626 (1971).
Adamson et al., Cancer Chemotherapy Reports, 59:599-610 (1975).
Warrell, Jr. et al., "Gallium in the Treatment of Hypercalcemia and Bone Metastasis" in Important Advances in Oncology 1989, Devita, Jr., Editor, J. P. Lippincott Company, Philadelphia, Pa.
Porter, "The Use of Opadry, Coateric, and Surelease in the Aqueous Film Coating of Pharmaceutical Oral Dosage Forms", at pp. 317-362 of Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, McGinity, Editor, Marcel Decker, Inc., New York, N.Y. (1989).
Nagai et al., "Applications of HPMC and HPHCAS Aqueous Film Coatings of Pharmaceutical Dosage Forms", pp. 81-152 in Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, McGinity, Editor, Marcel Decker, Inc., New York, N.Y. (1989).
Jones, "Production of Enteric Coated Capsules", Manufacturing Chemist & Aerosol News, 41:43-57 (1970).
Porter, "Coating of Pharmaceutical Dosage Forms", at Chapter 91, pp. 1633-1638, of Remington's Pharmaceutical Sciences, Gennaro et al., Editor, 17th Edition (1985).
Windholz et al., The Merck Index, 9th Edition, pp. 741-742, Merck & Company, Rahway, New Jersey (1976).
Finnegan et al., Inorganic Chemistry, 26:2171-2176 (1987).
Farrar et al., Food and Chemical Toxicology, 26:523-525 (1988).
Barrand et al., J. Pharm. Pharmacol., 39:203-211 (1987).
Ott, International Journal of Artificial Organs, 6:173-175 (1983).
Foster et al., "Gallium Nitrate: The Second Metal with Clinical Activity", Cancer Treatment Reports, 70:1311-1319 (1986).
Toray Ind., Inc., JP 292494, "Antitumor Platinum (II), Pyrone Complex" (1989) (Derwent Abstract Only).
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