Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-07-31
2007-07-31
Shameem, Golam M. M. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S240000, C548S247000
Reexamination Certificate
active
10969291
ABSTRACT:
The present invention relates to a pharmaceutical composition for the prevention and the treatment of cancers containing diaryl-isoxazole derivatives as an effective ingredient. Diaryl-isoxazole derivatives of the present invention inhibit metastasis of breast cancer cell lines and angiogenesis, so that they can be produced as a metastasis inhibitor and further as a pharmaceutical composition for the prevention and the treatment of angiogenesis related diseases including cancers, rheumatoid arthritis, psoriasis, or angiogenesis diseases caused in eyeball, etc.
REFERENCES:
Khilya et al (1990): STN International HCAPLUS database, Columbus (OH), accession No. 1990:631246.
P. Friedl et al., “Tumour-Cell Invasion And Migration: Diversity And Escape Mechanisms,” May 2003, Nature, 3:362-374.
J.L. Arbiser et al., “Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways,” Feb. 1997, Proc. Natl. Acad., Sci. USA, 94:861-866.
J. Folkman et al., “Angiogenic Factors,” Jan. 1987, Science, 235:442-447.
L.A. Liotta et al., “Cancer Metastasis and Angiogenesis: An Imbalance of Positive and Negative Regulation,” Jan. 1991, Cell, 64:327-336.
M.S. O'Reilly et al., “Angiostatin: A Novel Angiogenesis Inhibitor That Mediates the Suppression of Metastases by a Lewis Lung Carcinoma,” Oct. 1994, Cell, 79:315-328.
T. Fotsis et al., “Genistein, a dietary-derived inhibitor of in vitro angiogenesis,” Apr. 1993, Proc. Natl. Acad. Sci. USA, 90:2690-2694.
F.M. Uckun et al., “Biotherapy of B-Cell Precursor Leukemia by Targeting Genistein to CD19-Associated Tyrosine Kinases,” Feb. 1995, Science, 267:886-891.
Han Dong-Cho
Jeon Sun-Bok
Kwon Byoung-Mog
Lee Sang-Ku
Oh Jung-Hoon
Gates & Cooper LLP
Korea Research Institute of Bioscience and Biotechnology
Shameem Golam M. M.
LandOfFree
Pharmaceutical compositions of diaryl-isoxazole derivatives... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical compositions of diaryl-isoxazole derivatives..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions of diaryl-isoxazole derivatives... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3770108