Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Reexamination Certificate
2007-03-27
2007-03-27
Padmanabhan, Sreeni (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
C424S451000, C424S457000, C424S458000, C424S462000, C424S463000, C424S464000, C424S468000, C424S475000, C424S480000, C424S481000, C424S482000, C424S489000, C424S490000, C424S494000, C424S496000, C424S497000
Reexamination Certificate
active
10110134
ABSTRACT:
A pharmaceutical composition of anti-tubercular drugs for oral use comprising Rifampicin and/or Isoniazid wherein the bioavailability of Rifampicin and/or other drugs is enhanced. Preferably the bioavailability of Rifampicin is enhanced by preventing its degradation caused by presence of Isoniazid. Rifampicin and/or Isoniazid may be present in delayed release and/or extended release form such that minimal amount of the drug is dissolved between pH 1 and 4. preferably delayed release of Rifampicin and/or Isoniazid is achieved by treating the drugs with pH sensitive polymers.
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Shishoo et al (International Journal of Pharmaceutics 190 (1999), 109-123).
Eier et al (Therapy of tuberculosis, Wien Med Wochenschr, 1994; 144(8-9): 186-8).
Jain Rajesh
Singh Amarjit
Gollamudi Sharmila
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Panacea Biotec Limited
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