Pharmaceutical compositions of anagrelide and sulfinpyrazone

Details Pharmaceutical compositions of anagrelide and sulfinpyrazone Pharmaceutical compositions of anagrelide and sulfinpyrazone

1983-08-05

1984-04-24

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424273P, A61K 3147, A61K 31415

Patent

active

044447779

ABSTRACT:
Supra-additive blood platelet antiaggregation activity is observed with anagrelide in combination with those non-steroidal anti-inflammatory agents which are inhibitors of platelet cyclooxygenase. The supra-additive effects of such combinations make possible new compositions and methods for both therapeutic and prophylactic treatment of thrombosis and other disorders associated with blood platelet aggregation.

REFERENCES:
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J. Lab. Clin. Med. 95(2): 241-257, (1980), S. S. Tang et al.
Acta Univ. Carol. Med. Monogr. 72: 199-210, E. E. Polli et al.
Circulation 62: III-277, 1980, J. S. Fleming et al.
Thrombosis Research 15: 373-388, 1979, J. S. Fleming et al.
Platelets and Thrombosis, 1974, pp. 247-262, J. S. Fleming et al.
Fed. Proc. 38(3): 419, 1979, J. S. Fleming et al.
Br. J. Exp. Path. 58: 474-477, (1977), A. J. Honour et al.

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