Pharmaceutical compositions of a 105 kD P. Haemolytica derived a

Details Pharmaceutical compositions of a 105 kD P. Haemolytica derived a Pharmaceutical compositions of a 105 kD P. Haemolytica derived a

1987-08-13

1990-09-18

Draper, Garnette

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 424 858, 514 2, 514 8, 514 21, 530350, 530395, 530403, 530825, 4351723, 435 712, A61K 39102, C07K 1504

Patent

active

049577395

ABSTRACT:
Novel compositions are disclosed for use in the treatment or diagnosis of bovine pasteurellosis, commonly referred to as Shipping Fever. Cell-free Pasteurella haemolytica supernatants are employed to provide individual antigen compositions, identified through reaction with sera from naturally-infected or convalescent cattle. In particular, at least seven individual P. hameolytica antigen groups were recognized in cell-free culture supernatants. Purified P. haemolytica supernatant, formulated in a suitable pharmaceutical vaccine composition is shown to elicit a specific immune response, in both cows and rabbits, directed against the individual immunoreactive P. haemolytica polypeptides identified. Also disclosed are novel recombinant cells, plasmids and bacteriophage which include transcriptionally active P. haemolytica antigen genes. Recombinant clones are similarly selected to be reactive with naturally-infected antisera. Examples, and further disclosure, are also provided which demonstrate the utility of a presently disclosed antibody and antigen compositions in immunodetection of both antigens and antibodies in various biological samples.

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