Pharmaceutical compositions, novel uses, and novel form of .alph

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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424451, 424464, 424 43, 514 78, 514458, A61K 9127, A61K 31685, A61K 31355

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active

060225602

ABSTRACT:
.alpha.-Tocopherylphosphocholine and salts thereof have been discovered to possess antiviral, anti-fungal, anti-inflammatory, PAF-antagonist, and ultra-violet radiation-blocking activities. The compound and salts have also been discovered to be capable of forming liposomes. The present invention thus provides methods of treating viral and fungal infections, inflammatory disorders and pathophysiological conditions due to PAF activity in a mammal by administering to the mammal .alpha.-tocopherylphosphocholine or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions comprising .alpha.-tocopherylphosphocholine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. Further, the invention provides liposomes which comprise .alpha.-tocopherylphosphocholine or a salt thereof as a structural component of the liposome bilayer.

REFERENCES:
patent: 4861580 (1989-08-01), Janoff
patent: 5763423 (1998-06-01), Yazdi
Raschke, W.C.; Baird, S.; Ralph, P. and Nakoinz, I., Functional Macrophage Cell Lines Transformed by Abelson Leukemia Virus, Cell (1978), 15:261-267.
Cohen et al., Total Synthesis of All Eight Stereoisomers of .alpha.-Tocopheryl Acetate. Determination of Their Diastereoisomeric and Enantiomeric Purity by Gas Chromatography, Helv. Chimica Acta. (1981), 64:1158-1173.
Chan et al., Synthesis of (2R,4'R,8"R)-.alpha.-Tocopheryl Acetate (Vitamin E. Acetate) Using [3,3] Sigmatropic Rearrangement, J. Org. Chem. (1978), 43:3435-3440.
Erlich et al., Searching For Antiviral Materials From Microbial Fermentations, Ann. NY Acad. Sci. (1965), 130:5-16.
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Ralph, P. and Nakoinz, Ilona, Antibody-Dependent Killing of Erythrocyte and Tumor Targets by Macrophage-Related Cell Lines: Enhancement by PPD and LPS, J. Immunology (1977), 119:950-954.
Robeson et al., Isolation of an l-Epimer of Natural d-.alpha.-Tocopherol, J. Am. Chem. Soc. (1962), 84:3196-3197.
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Ostro in Amer. J. of Hospital Pharmacy. 46, p. 1576 1989.

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