Pharmaceutical compositions including mixtures of an adenosine c

Details Pharmaceutical compositions including mixtures of an adenosine c Pharmaceutical compositions including mixtures of an adenosine c

1994-11-17

1997-10-21

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 47, 514221, 514258, 514261, 514270, 514282, 514399, 514653, 514731, 536 2623, 536 26256, 536 2627, 536 276, 564374, A61K 3170, A61K 31135, C07H 19167, C07H21100

Patent

active

056796501

ABSTRACT:
A purine compound, which has a desired and an undesired effect when a dosage sufficient to induce the desired effect is administered to a mammal, is combined with a counteracting agent, wherein the counteracting agent can reduce the undesired effect when the combination containing an effective amount of the purine compound is administered to a mammal. In a preferred embodiment, an adenosine compound is combined in vitro with a catecholamine in a predetermined ratio to form an adenosine composition. Very high dosages of a purine compound, such as adenosine, ATP or their analogs can be administered to a mammal via administration of compositions containing the purine compound and a counteracting agent, while reducing the dangerous, undesired effects associated with administering the same dosage of purine compound without first combining it with the counteracting agent. New catecholamine compositions are also taught. The purine and catecholamine compositions of the present invention pioneer new therapies which take advantage of the diversity of physiological effects of purine and catecholamine compounds.

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