Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-05-10
2005-05-10
Henley, III, Raymond J. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S466000, C514S562000
Reexamination Certificate
active
06890918
ABSTRACT:
A pharmaceutical composition comprising an inhibitor of angiotensin converting enzyme and neutral endopeptidase, such as sampatrilat, and at least one bioavailability enhancer such as an organic acid, e.g., ascorbic acid. Such a composition has improved systemic bioavailability.
REFERENCES:
patent: 4454125 (1984-06-01), Demopoulos
patent: 4975444 (1990-12-01), Danilewicz et al.
patent: 5897876 (1999-04-01), Rudnic et al.
patent: WO 9965500 (1999-12-01), None
Structure of Sampatrilat, Merck Index Abstract # 8428 (2004).*
EP International Search Report dated Sep. 4, 2002 of PCT/US02/13301.
EP International Search Report dated Sep. 4, 2002.
Burnside Beth
Chang Rong-Kun
Shojaei Amir
Henley III Raymond J.
Lane M. Elisa
Shire Laboratories Inc.
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