Pharmaceutical compositions including ACE/NEP inhibitors and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S466000, C514S562000

Reexamination Certificate

active

06890918

ABSTRACT:
A pharmaceutical composition comprising an inhibitor of angiotensin converting enzyme and neutral endopeptidase, such as sampatrilat, and at least one bioavailability enhancer such as an organic acid, e.g., ascorbic acid. Such a composition has improved systemic bioavailability.

REFERENCES:
patent: 4454125 (1984-06-01), Demopoulos
patent: 4975444 (1990-12-01), Danilewicz et al.
patent: 5897876 (1999-04-01), Rudnic et al.
patent: WO 9965500 (1999-12-01), None
Structure of Sampatrilat, Merck Index Abstract # 8428 (2004).*
EP International Search Report dated Sep. 4, 2002 of PCT/US02/13301.
EP International Search Report dated Sep. 4, 2002.

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