Pharmaceutical compositions in the form of stable sucralfate sus

Details Pharmaceutical compositions in the form of stable sucralfate sus Pharmaceutical compositions in the form of stable sucralfate sus

1990-01-08

1994-06-14

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 41, 536118, 536121, A61K 3170, C07H 100

Patent

active

053210131

ABSTRACT:
Pharmaceutical compositions in the form of stable sucralfate suspensions free of suspending agents, wherein the sucralfate is present in the form of a gel having self-suspending properties and is suspended in an aqueous carbohydrate solution in a quantity of between 1 and 40% of sucralfate by weight.
Said gel has a surface area exceeding 200 m.sup.2 /g and is prepared by dissolving powdered sucralfate in an HCl solution and then precipitating it with an NaOH solution added to a pH of between 4 and 4.5.

REFERENCES:
R. Nagashima and N. Yoshida, "Sucralfate, a Basic Aluminum Salt of Sucrose Sulfate", Drug Res. 29(II), No. 11 (1979) pp. 1668-1676.
Casillan et al., "Sucralfate suspension for use in treating ulcers", Chemical Abstracts vol. 102 (1985) No. 209472z.

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