Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1987-12-31
1989-02-28
Lusignan, Michael
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424469, 424489, A61K 914, A61K 926, A61K 952
Patent
active
048084131
ABSTRACT:
A pharmaceutical composition is provided which is in the form of a plurality of beadlets, adapted to be filled into pharmaceutical hard shell capsules, or compressed into tablets, which beadlets are formed of a pharmaceutical such as an ACE inhibitor, for example, captopril, a beta-blocker such as nadolol, propranolol or atenolol, a calcium channel blocker such as diltiazem or nifedipine or other pharmaceuticals including combinations thereof, binder such as microcrystalline cellulose, and at least 5% by weight of an acid processing aid, such as citric acid, which imparts plasticity to the wet mass needed for efficient extrusion and spheronization. A method for forming beadlets is also provided which includes the steps of extruding a composition as described above, and subjecting the resulting extrudate to a spheronization step wherein an acid processing aid such as citric acid is employed to improve processing and form improved beadlets.
Bachman William R.
Jain Nemichand B.
Joshi Yatindra M.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Lusignan Michael
Rodney Burton
LandOfFree
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