Pharmaceutical compositions having therapeutical activity based

Details Pharmaceutical compositions having therapeutical activity based Pharmaceutical compositions having therapeutical activity based

1992-10-13

1993-09-14

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514578, 562112, A61K 31205, A61K 3185, C07C 900

Patent

active

052449203

ABSTRACT:
The L-arginine salts of the mercaptoethansulphonic acid are active in the therapy of the bladder carcinoma and in the therapy and prevention of the cistinic kidney calculi.
The saline derivatives with basic aminoacids and their alkyl esters are moreover devoid of side effects.
The latter derivatives are prepared by reacting, in aqueous or aqueous-alcoholic medium, equimolar amounts of mercaptoethansulphonic acid, just prepared from an organic or inorganic salt thereof, and of the desired aminoacid.

REFERENCES:
patent: 2694723 (1954-11-01), Schramm
patent: 2695310 (1954-11-01), Schramm
patent: 3567835 (1971-03-01), Moner
patent: 4105785 (1978-08-01), Ondetti
patent: 4220660 (1980-08-01), Brock
patent: 4254274 (1981-03-01), Tersada
patent: 4362891 (1982-12-01), Guerrato
patent: 4418206 (1983-11-01), Wren
patent: 4503072 (1985-03-01), Hoffman
Wilson "Textbook of Organic Medicinal and Pharmaceutical Chemistry", 7th Edition, p. 69 (1977).
Zehninger, "Biochemistry", 2nd Ed, pp. 71-76 (1970).
Sacha, C.A.:97: 127045b (1982).
Roccini et al, Advances in Urological Oncology and Endocrinology, Acta Medica, 1984 (pp. 391-397).

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