Pharmaceutical compositions having therapeutical activity based

Details Pharmaceutical compositions having therapeutical activity based Pharmaceutical compositions having therapeutical activity based

1989-05-02

1991-05-28

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

A61K 31185

Patent

active

050195964

ABSTRACT:
Derivatives of mercapthansulphonic acid are active in the therapy of the bladder carcinoma and in the therapy and prevention of the cistinic kidney calculi. The saline derivatives with basic aminoacids and their alkyl esters are moreover devoid of side effects. The saline derivatives are prepared by reacting, in aqueous or aqueous-alcoholic medium, equimolar amounts of mercaptoethansulphonic acid, just prepared from an organic or inorganic salt thereof, and of the desired aminoacid.

REFERENCES:
patent: 2694723 (1954-11-01), Schramm
patent: 2695310 (1954-11-01), Schramm
patent: 3567835 (1971-03-01), Morren
patent: 4105789 (1978-08-01), Ondetti
patent: 4220660 (1980-09-01), Brock
patent: 4254274 (1981-03-01), Terada
patent: 4362891 (1982-12-01), Guerrato
patent: 4418206 (1983-11-01), Wren
patent: 4503072 (1985-03-01), Hoffman
Wilson, "Textbook of Organic Medicinal and Pharmaceutical Chemistry," 7th Ed., p. 69 (1977).
Lehninger, "Biochemistry," 2nd Ed., pp. 71-76 (1970).
Sacha, Chem. Abst., 97: 127045b (1982).
"Advances in Urological Oncology & Endocrinology", Acta Medica, 1984, pp. 391-397.
"Mercaptoethane Sulphonate in Cystinic Calculosis Therapy", F. Di Silverio et al., Contributions to Nephrology, vol. 58, pp. 193-195, 1987.

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