Pharmaceutical compositions having steroid nitrate ester derivat

Details Pharmaceutical compositions having steroid nitrate ester derivat Pharmaceutical compositions having steroid nitrate ester derivat

1996-05-02

1999-11-16

Jones, Dwayne C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514174, 552276, A01N 4500

Patent

active

059858621

ABSTRACT:
The present invention discloses novel pharmaceutical compositions having steroid nitrate ester(ONO.sub.2) derivatives, and to their use treating undesired smooth muscle contractions and inflammatory diseases.

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Moncada et al, Biochem.Pharm. 38:1709-1715 (1989).
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Persson et al., Eur.Jour.Pharm. 249 R7-R8 (1993).
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Wallace et al., Eur.Jour.Pharm. 257:249-255 (1994).
MacIntyre et al., Proc.Nat.Acad.Sci. USA 88 2936-2940 (1991).
Pipili-Synetos et al, Britis Journal of Pharmacology 116, 1829-1834 (1995).

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