Pharmaceutical compositions having good stability

Details Pharmaceutical compositions having good stability Pharmaceutical compositions having good stability

1988-03-31

1991-07-09

Page, Thurman

Drug, bio-affecting and body treating compositions

Lymphokine

424 83, 424468, 424470, 424465, 514510, 514548, A61K 3179, A61K 920

Patent

active

050304470

ABSTRACT:
A pharmaceutical compositions is provided which has excellent stability, when dispersed in water has a pH of at least about 9, and includes a medicament which is sensitive to a low pH environment such as pravastatin, one or more fillers such as lactose and/or microcrystalline cellulose, one or more binders, such as mirocrystalline cellulose (dry binder) or polyvinylpyrrolidone (wet binder), one or more disintegrating agents such as croscarmellose sodium, one or more lubricants such as magnesium stearate and one or more basifying agents such as magnesium oxide.

REFERENCES:
patent: 3865935 (1975-02-01), Amann
patent: 3891755 (1975-11-01), Mehta
patent: 4342767 (1982-08-01), Albert-Schoenberg
patent: 4342767 (1982-08-01), Albers-Schonberg
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4609675 (1986-09-01), Franz
patent: 4609675 (1986-09-01), Franz
patent: 4681759 (1987-07-01), Porubcan
patent: 4755385 (1988-07-01), Etienne et al.

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