Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-22
1996-04-09
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3142
Patent
active
055062482
ABSTRACT:
An ifetroban composition is provided which has good dissolution properties even on aging, when dispersed in water has a pH of at least 7 and includes a salt of ifetroban, one or more basifying agents, such as magnesium oxide or calcium carbonate, and where in tablet form includes one or more fillers such as mannitol and/or microcrystalline cellulose, one or more disintegrating agents such as crospovidone, one or more lubricants such as magnesium stearate, optionally one or more glidants such as colloidal silicon dioxide, one or more binders such as pregelatinized starch (dry binder) or polyvinyl-pyrrolidone (wet binder) and optionally a film coating containing a film former such as hydroxypropyl cellulose and a plasticizer such as 1,2,3-propanetriol triacetate.
REFERENCES:
patent: 5030447 (1991-07-01), Joshe et al.
patent: 5100889 (1992-03-01), Misra et al.
patent: 5180589 (1993-01-01), Joshi et al.
Remington's Pharmaceutical Sciences, 16th edition (1980) pp. 1555-1557.
The Handbook of Pharmaceutical Excipients .COPYRGT. 1986 by APL A, pp. 26-29.
Jain Nemichand B.
Jerzewski Robert L.
Nikfar Faranak
Serajuddin Abu T. M.
Bristol--Myers Squibb Company
Henley III Raymond
Rodney Burton
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