Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1987-10-07
1989-10-03
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
514 11, 514922, A61K 3700
Patent
active
048715280
ABSTRACT:
Pharmaceutical compositions containing unit or separate dosages of 2.5 to 5 grams of reduced glutathione (GSH) and known anti-tumor agents, to be used simultaneously, separately or sequentially in anti-tumor therapy.
Compounds of the invention, that can be used both in mono- or polychemotherapy, reach surprising results against tumors, thus avoiding the onset of dangerous side-effects, such as nephrotoxicity induced by cisplatinum, and increasing the long term survival rates.
REFERENCES:
Yoda et al., "Prevention of Doxorubicin Myocardial Toxicity in Mice by Reduced Glutathione," Cancer Research 46, 2551-2556, May 1986.
Zunino et al., "Protective effect of reduced glutathione Against Cis-Dichlorodiammine Platinum (II)-induced Nephrotoxicity and Lethal Toxicity", Tumori 60:105-111, 1983.
Leszynska et al., Chem. Abst. 97(13):103887b (1982).
Danysz et al., Chem. Abst. 102 (9):72513S (1985).
Danysz et al., Chem. Abst. 100 (9):61471j (1984).
Danysz et al., Chem. Abst. 102 (25):216427V (1985).
Tofametti et al., Chem. Abst. 103 (17):134586Z (1985).
Assereto Roberto
Cavalletti Ennio
Tedeschi Michele
Tofanetti Odoardo
Tognella Sergio
Armstrong Nikaido
Boehringer Biochemia Robin SpA
Kearse Richard
Robinson Douglas W.
LandOfFree
Pharmaceutical compositions having antineoplastic activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical compositions having antineoplastic activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions having antineoplastic activity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-662816