Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai
Patent
1989-03-03
1991-04-16
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heavy metal containing doai
514706, A61K 3128, A61K 31095
Patent
active
050082876
ABSTRACT:
Compositions containing as antineoplastic active principloe only dialkyl diselenides show a very promising activity not withstanding a remarkably lower toxicity in comparison with that of known combinations of the same dialkyldi selenides with other active principles.
REFERENCES:
patent: 4681753 (1987-07-01), Revili
Schwarz et al., "Biological Potency of Organic Selenium Compounds IV, Straight-Chain Dialkylmono- and Diselenides", Bioinorganic Chemistry 3, 145-152 (1974).
2nd Int. Conf. Anticancer Res., vol. 8, (5 Part B), Oct. 11-15, 1988, pp. 1097-1098, Abstract 254; G. Scambia et al.: "Growth Inhibitory Effect of Diheptyl Diselenide (DHDSe) on Human Cancer in Vitro".
Journal Med. Chem., vol. 30, No. 4, 1987 pp. 597-602, Am. Chem. Soc.; S.-I. Kang et al.: "Linear Free Energy Relationships and Cytotoxicities of Para-Substitutes 2-Haloethyl Aryl Selenides and Bis(2-Chloroethyl)Selenides".
Journal of Pharmaceutical Sciences, vol. 69, No. 10, Oct. 1980, Am. Pharm. Ass.; Y. A. Beltagy et al.: "Antioxidants in Purification, Stabilization, and Formulation of the Antineoplastic Agent 6-Selenoguanosine".
Anticancer Research, vol. 9, 1989, pp. 1697-1700; G. Scambia et al.: "Growth Inhibitory Effect of Diheptyl Diselenide on Various Human Cancer Cell Lines".
Bioinorg. Chem., vol. 3, No. 2, 1974, pp. 145-152, Am. Elsevier Publ. Comn., Inc.; K. Schwarz et al.: "Biological Potency of Organic Selenium Compounds IV. Straight-Chain Dialkylmono-and Diselenides".
Goldberg Jerome D.
Onco-Pharm Development AG
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