Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1981-10-09
1984-02-14
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424262, 424263, 424274, A61K 3133, A61K 3140, A61K 3144, A61K 31475
Patent
active
044316410
ABSTRACT:
The present invention relates to novel pharmaceutical compositions having antiepileptic and antineuraglic action and containing (a) at least one anticonvulsive compound of the general formula I ##STR1## wherein X.sub.1 is hydrogen, halogen having an atomic number up to 35, or is cyano, and X.sub.2 and Y together are an additional bond, or X.sub.1 and X.sub.2 together are the oxo radical, or X.sub.1 is hydroxy, X.sub.2 is hydrogen and Y is also hydrogen, and (b) at least one nootropic compound of the vincamine type which has the general formula II ##STR2## wherein Z.sub.1 is lower alkoxycarbonyl, Z.sub.2 is hydroxy and Z.sub.3 is hydrogen, or Z.sub.2 and Z.sub.3 together are an additional bond, or one of Z.sub.1 and Z.sub.2 is hydroxy and the other is hydrogen and Z.sub.3 is also hydrogen, in particular vincamine (DCI rec.), in which Z.sub.1 is methoxycarbonyl, Z.sub.2 is hydroxy and Z.sub.3 is hydrogen, and also e.g., vinpocetin (DCI rec.), in which Z.sub.1 is ethoxycarbonyl and Z.sub.2 and Z.sub.3 together form an additional bond, as well as vincanol (DCI prop.), in which one of Z.sub.1 and Z.sub.2 is hydroxy and the other is hydrogen and Z.sub.3 is hydrogen, and the acid addition salts thereof, or at least one nootropic derivative of 2-pyrrolidinone, e.g. 2-oxo-1-pyrrolidineaetamide (piracetam) or one of its nootropic derivatives. The compounds of the general formula II e.g. vincamine, as well as the nootropic derivatives of 2-pyrrolidinone, e.g. piracetam, have in themselves virtually no anticonvulsive activity but potentiate the action of the compounds of the general formula I, e.g. carbamazepine.
REFERENCES:
patent: 4076812 (1978-02-01), Allgeir et al.
Martin Negwer: Organisch-chemische Arzneimittel and Ihre Synonyma 5 Edition, vol. 1, p. 487 (1978).
Dictionaire Vidal: Edition 1982, p. 893.
Chem. Abst. 92, 34353g (1980).
Chem. Abstract, 72 41379k (1972).
B. M. Kulig et al., Adv. Epileptol, Proc. Comgr. Int. League Epilepsey, 13th (1977) pp. 89-103/CA90-115155e.
Jacobides, G. M., Adv. Epileptol, Proc. Congr. Int. League Epilepsey, 13th, 1977 pp. 114-119 CA 90-11539N.
S. J. Sara et al., Psychopharmacologia 25, 32-40 (1972).
Boggan et al., Behavioral Biology, 12 127--134 (1974).
Mondadori Cesare
Schmutz Markus
Ciba-Geigy Corporation
Feit Irving N.
Friedman Stanley J.
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