Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-06-07
2000-09-05
Scheiner, Laurie
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424400, 514 1, A61F 606
Patent
active
061139394
ABSTRACT:
A composition for the treatment of impotence via delivery to the urethra comprises a vasoactive prostaglandin and a polyethylene glycol dispersant having sufficient viscosity to be retained without spillage from a urethra receivable insert. The composition can additionally contain an .alpha.-blocker. Suppositories can be formulated that are small enough for administration to the male urethra, and that dissolve, melt or bioerode within the urethra to release the active agent(s). The suppositories can contain vasodilators other than prostaglandins as the active for the treatment of impotence. Suppositories can also be formulated that contain active agents useful in the treatment of priapism or Peyronie's syndrome.
REFERENCES:
patent: 4784855 (1988-11-01), Yamashita et al.
patent: 5152997 (1992-10-01), Ebert et al.
patent: 5236904 (1993-08-01), Gerstenberg et al.
Schramek et al., 1990, Brit. J. Urol. 65:68-71.
Earle et al., 1990, J. Urol. 143:57-59.
Bertsch et al., 1981, Eur. J. Rheum. Inflam. 4:250-259, see attached abstract.
Molina et al., 1989, J. Urol. 141:1127-8, see attached abstract.
Malloy, T.R., et al., "Pharmacological treatment of impotence", Urologic Clinics of North America 14(2):297-305 [see 303-304] (1987).
Klinge, E., et al., "Comparative study of some isolated mammalian smooth muscle effectors of penile erection", Urol. Res., vol. 100:35467 (1977).
Ahmad, S., "Scleroderma and impotence: Response to nitroglycerin applied to the fingers and penis", South Med. J. 83:1495 (1990).
Talley, J.D., et al., "Transdermal nitrate, penile erection and spousal headache", Ann. Intern. Med. 103:804 (1985).
Yamamura, K., et al., "High-Performance Liquid Chromatographic Assay for Prostaglandin E1 in Various Ointment Vehicles", J.Chromatography 303:165-172 (1984).
Sundaram, M.B.M., "Seizures After Intraurethral Instillation of Lidocaine," Canad. Med. Assn. J. 137:219-220 (1987).
Negelev, S., "Tropical nitroglycerin: a potential treatment for impotence", J. Urol. 143:586 (1990).
Robinette, M.A., et al., "Intracorporal Injection of Papaverine and Phentolamin in the Management of Impotence", Br. J. Urology 58:692-695 (1986).
Heaton, J.P.W., et al., "Tropical glyceryltrinitrate causes measurable penile arterial dilation in impotent men.", J. Urology 143:729-731 (1990).
Owen, J., et al., "Transcutaneous Nitroglycerine Enhances the Quality of Erections in Impotent Men. Results of a Controlled Trial", J. Urol., 137, 201A, abstract 392 (1987).
Claes, H., et al., "Transcutaneous Nitroglycerin Therapy in the Treatment of Impotence", Urol. Int., 44:309-312 (1989).
Zorgniotti, A.W., et al., "Auto-injection of the Corpus Cavernosum with a Vasoactive Drug Combination for Vasculogenic Impotence" J. Urol., 133:39-41 (1985).
Rudd., et al., The Pharmacological Basis of Therapeutics, Gilman et al. (Eds) 7th Ed., Chap. 32 pp. 784-785 (1985).
Turner, J.E., et al., "Prostaglandin E.sub.2 in Tylose Gel for Cervical Ripening Before Induction of Labor", J. Reprod. Med., 32(11):815-821 (1987).
Andersson, K.E., et al., "Effects of Prostaglandin E.sub.2 Applied Locally on Intravesical and Intraurethral Pressures in Women", Eur. Urol., 4(5):366-369 (1978).
Axelsson, K., et al., "Blood Concentration of Lignocaine after Application of 2% Lignocaine Gel in the Urethra", Br. J. Urol., 55(1):64-68 (1983).
Anonymous, "Intracavernous injections for impotence", The Medical Letter 751:39.95 (1987).
Brindley, G.S., "Cavernosal alpha-blockage: A new technique for investigating an treating erectile impotence", Brit. K. Psychiatr., 143:332-377 (1983).
Brindley, G.S., "Pilot experiments on the actions of drugs injected into the human corpus cavernosum penis", Br. J. Pharmacol, 87:495-500 (1986).
ISHII, N., et al., "Studies on male sexual impotence. Report 18. Therapeutic trial with prostaglandin E1 for organic impotence", 77:954-962 (1986).
Stackl, W., et al., "Intracavernous injection o prostaglandin E1 in impotent men", J. Urol., 140:66-68 (1988).
Virag, R., "Intracavernous injection of papaverine for erectile failure" [leeter], Lancet, 2:938 (1982).
Berggren Randall G.
Gale Robert M.
Place Virgil A.
Parkin Jeffrey S.
Reed Dianne E.
Scheiner Laurie
Vivus Inc.
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