Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing
Reexamination Certificate
2004-10-15
2008-07-15
Kemmerer, Elizabeth C. (Department: 1649)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
C435S069100, C435S219000, C435S226000, C435S320100, C435S325000, C435S252300, C435S254110, C530S350000, C536S023500
Reexamination Certificate
active
07399465
ABSTRACT:
The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors. Also provided are methods for identifying additional compounds that influence TNF receptor shedding. As the active ingredient in a pharmaceutical composition, the products of this invention increase or decrease TNF signal transduction, thereby alleviating the pathology of disease.
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Chitam
Gatanaga Tetsuya
Granger Gale A.
Bozicevic Field & Francis LLP
Emch Gregory S
Francis Carol L.
Kemmerer Elizabeth C.
The Regents of the University of California
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