Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Alkali or alkaline earth chloride
Reexamination Certificate
2007-12-18
2007-12-18
Pak, John (Department: 1616)
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Alkali or alkaline earth chloride
C424S678000, C424S679000, C424S697000, C424S717000, C514S002600, C514S023000, C514S054000, C514S059000, C514S460000, C514S557000, C514S669000, C514S774000, C514S823000, C514S833000, C514S921000
Reexamination Certificate
active
11198696
ABSTRACT:
The present invention relates to a pharmaceutical composition and the method for the preparation thereof. The composition comprises 1.5˜6.9% (w/v) of one or more substances selected from sodium chloride, sodium bicarbonate, potassium chloride, magnesium sulfate, calcium chloride, calcium gluconate, and the like, and 3˜18% (w/v) of one or more substances selected from hydroxyethylstarch, dextran, carboxymethylstarch, polyvinyl-pyrrolidone, gelatin derivatives, and the like as well as the remainder of conventional injections, as long as sodium chloride is not less than 1.5% (w/v). The pharmaceutical composition of the present invention is used to treat and save the wounded and patients, as well as to treat shock, its advantages include safe and convention use, rapid and good curative effect, long time maintenance, extensive uses and the like.
REFERENCES:
Dubick, M.A. et al., “Issues of concern regarding the use of hypertonic/hyperoncotic fluid resuscitation of hemorrhagic hypotension,” Shock, vol. 25, No. 4, pp. 321-328 (2006).
Sheikh, A.A. et al., “Cerebral effects of resuscitation with hypertonic saline and a new low-sodium hypertonic fluid in hemorrhagic shock and head injury,” Critical Care Medicine, vol. 24, No. 7, pp. 1226-1232 (1996).
Velasco, R.T. et al., “Experimental basis for small-volume resuscitation: Physiologic mechanism for the circulatory effects provoked by hyperosmolar sodium chloride,” Clencia e Cultura Journal of the Brazilian Association for the Advancement of Science, vol. 52(6), Dec. 2000, pp. 372-376.
Mayback Gregory L.
Mayback & Hoffman P.A.
Pak John
Smiley Scott D.
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